The research is aimed at understanding the structure of the plant genome, and at exploring and clarifying the physiological functions deriving from genomic diversity.
The Department of Applied Genomics was set up by the Agricultural Research Institute of the Hungarian Academy of Sciences at the end of 2004 to function as a research, development and innovation base equipped with up-to-date instruments, capable of serving the basic and applied research and development needs of both the institute and of scientists working in universities, research institutes and companies in the Central Transdanubia Region, especially in the fields of breeding, molecular biology and genomics. A further aim was to provide a head start for the biotechnological and breeding spin-off companies associated with the institute, and to enhance cooperation between the business and academic sectors.
At present several research projects are underway in the department. One is concerned with the identification and analysis of the allergenic proteins present in species related to wheat, with special focus on the wild and cultivated einkorn genotypes maintained in the Martonvásár Cereal Gene Bank. Another uses the most up-to-date methods available to bioinformatics, network analysis and in vitro tissue culturing to obtain a better understanding of how the genes coding for storage proteins are regulated. The strigolactone signalling project aims to determine how these newly described plant hormones regulate plant development and architecture, in particular light-dependent signal transduction and branching. The cucumber mosaic virus project seeks to gain more detailed information on the action mechanism of virus infection at the molecular level in the interests of more successful protection.
3D model of an Astrovirus. Tissue-specific spike protein dimers (blue) located on the surface of the astrovirus particle.
(Photo: Dr. Ákos Gellért)
Detection of DLK2 gene expression with GUS staining in Arabidopsis tissues.
(Photo: Dr. Vilmos Soós)
Gell Gy, Kovács K, Veres G, Korponay-Szabó I and Juhász A (2017) Characterization of globulin storage proteins of a low prolamin cereal species in relation to celiac disease. Sci Rep. 7:39876, doi: 10.1038/srep3987
Juhász A, Haraszi R, Maulis C (2015) ProPepper: a curated database for identification and analysis of peptide and immune-responsive epitope composition of cereal grain protein families. Database Vol. 2015: article ID bav100; doi:10.1093/database/bav100
Makai S, Éva C, Tamás L, Juhász A (2015) Multiple elements controlling the expression of wheat high molecular weight glutenin paralogs. Funct Integr Genomics. 15(6):661-72. doi: 10.1007/s10142-015-0441-4.
Gell Gy, Kovács K, Molnár I, Bugyi Zs, Tömösközi S, Juhász A (2015) Celiac disease specific prolamin peptide content of wheat relatives and wild species determined by ELISA assays and bioinformatics analyses. Cereal Res Commun. 43:1. 133-143. doi: 10.1556/CRC.43.2015.1.13
Gell Gy, Sebestyén E, Balázs E (2015) Recombination analysis of Maize dwarf mosaic virus (MDMV) in the Sugarcane mosaic virus (SCMV) subgroup of potyviruses. Virus Genes. 50(1):79-86. doi: 10.1007/s11262-014-1142-0
Juhász A, Gell Gy, Békés F, Balázs E (2012) The epitopes in wheat proteins for defining toxic units relevant to human health. Funct Integr Genomics. 12(4) 585-598, DOI 10.1007/s10142-012-0302-3
Soós V, Sebestyén E, Posta M, Light ME, Kohout L, Van Staden J and Balázs E (2012) Molecular aspects of the antagonistic interaction of smoke derived butenolides on the germination process of Grand Rapids lettuce achenes. New Phytol 196(4):106073. 10.1111/j.1469-8137.2012.04358.x
Gellért Á, Salánki K, Tombácz K, Tuboly T, Balázs E (2012) A Cucumber Mosaic Virus Based Expression System for the Production of Porcine Circovirus Specific Vaccines. PLOS ONE 7:(12) p. 52688. doi:10.1371/journal.pone.0052688
Juhász A, Makai Sz, Sebestyén E, Tamás L and E Balázs (2011) Role of conserved non-coding regulatory elements in LMW glutenin gene expression. PLoS ONE doi:10.1371/journal.pone.0029501
Soós V, Sebestyén E, Juhász A, Szalai G, Tandori J, Light ME, Kohout L, Van Staden J and Balázs E (2010) Transcriptome analysis of germinating maize kernels reveals substantial differences between the effects of smokewater and the active compound KAR1. BMC Plant Biol 10: 236. 10.1186/1471-2229-10-236